From premorbid adjustment dimensions to clinical outcomes: Exploring environmental stress and epigenetic influences on first-episode schizophrenia phenotypes.

doi:10.1016/j.sjpmh.2025.08.002

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Article

From premorbid adjustment dimensions to clinical outcomes: Exploring environmental stress and epigenetic influences on first-episode schizophrenia phenotypes.

Spanish journal of psychiatry and mental health - 1 Jan 2026

Pérez-Ramos Anaid, Gonzalez-Segura Àlex, Julià Laura, García-Rizo Clemente, Sánchez-Torres Ana, Cavone Vito, Zorrilla Iñaki, Mané Anna, Rodriguez-Jimenez Roberto, Roldan Alexandra, Pomarol-Clotet Edith, Ibañez Angela, Usall Judith, Lobo Antonio, Bioque Miquel, Bernardo Miquel, Cuesta Manuel J, Parellada Mara, González-Pinto Ana, Berrocoso Esther, Amoretti Silvia, Mezquida Gisela

Abstract excerpt

INTRODUCTION: Schizophrenia is a complex and multifaceted mental disorder characterized by cognitive, emotional, and behavioral dysfunctions that significantly impact the patients' daily lives. Premorbid adjustment (PA) is a multidimensional framework, the severity of which has been associated with more severe phenotypic traits and unfavorable outcomes, offering insights into the development of this disorder....

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PMID: 41242552
DOI: 10.1016/j.sjpmh.2025.08.002

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