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Article

Executive function mediates the effects of genetic liability to schizophrenia on behavior and functioning in a community sample of children and adolescents.

Schizophrenia research - 1 Apr 2026

Fonseca Lais, Ito Lucas Toshio, Ziebold Carolina, Rohde Luis A, Miguel Eurípedes C, Bressan Rodrigo A, Pan Pedro M, Belangero Sintia I, Santoro Marcos L, Gomes Felipe V, Grace Anthony A, Gadelha Ary

Abstract excerpt

BACKGROUND: Genetic liability for schizophrenia has been associated with cognitive deficits and clinical phenotypes during neurodevelopment. However, the possible role of executive function (EF) as a mediator between the polygenic risk score for schizophrenia (PRS-SZ) and subsequent outcomes, including transdiagnostic general psychopathology (the p-factor), has yet to be examined. In this study, we investigated...

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PMID: 41592516
DOI: 10.1016/j.schres.2026.01.014

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