Article
Cell-Free DNA Detection of Tumor Mutations in Heterogeneous, Localized Prostate Cancer Via Targeted, Multiregion Sequencing.
JCO precision oncology - 1 Jan 2021
Chen Emmalyn, Cario Clinton L, Leong Lancelote, Lopez Karen, Márquez César P, Li Patricia S, Oropeza Erica, Tenggara Imelda, Cowan Janet, Simko Jeffry P, Kageyama Robin, Wells Daniel K, Chan June M, Friedlander Terence, Aggarwal Rahul, Paris Pamela L, Feng Felix, Carroll Peter R, Witte John S
Abstract excerpt
Cell-free DNA (cfDNA) may allow for minimally invasive identification of biologically relevant genomic alterations and genetically distinct tumor subclones. Although existing biomarkers may detect localized prostate cancer, additional strategies interrogating genomic heterogeneity are necessary for identifying and monitoring aggressive disease. In this study, we aimed to evaluate whether circulating tumor DNA can...
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