Article
Multifocal Primary Prostate Cancer Exhibits High Degree of Genomic Heterogeneity.
European urology - 1 Mar 2019
Løvf Marthe, Zhao Sen, Axcrona Ulrika, Johannessen Bjarne, Bakken Anne Cathrine, Carm Kristina Totland, Hoff Andreas M, Myklebost Ola, Meza-Zepeda Leonardo A, Lie A Kathrine, Axcrona Karol, Lothe Ragnhild A, Skotheim Rolf I
Abstract excerpt
BACKGROUND: Most primary prostate cancers are multifocal with individual tumors harboring different aggressiveness; however, the genomic heterogeneity among these tumors is poorly understood. OBJECTIVE: To better understand the biological basis for clinical variability among different lesions, we sought to comprehensively characterize the heterogeneity of somatic gene mutations in multifocal prostate cancer....
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