Article
Disruption of MAM integrity in mutant FUS oligodendroglial progenitors from hiPSCs.
Acta neuropathologica - 3 Jan 2024
Zhu Yingli, Burg Thibaut, Neyrinck Katrien, Vervliet Tim, Nami Fatemeharefeh, Vervoort Ellen, Ahuja Karan, Sassano Maria Livia, Chai Yoke Chin, Tharkeshwar Arun Kumar, De Smedt Jonathan, Hu Haibo, Bultynck Geert, Agostinis Patrizia, Swinnen Johannes V, Van Den Bosch Ludo, da Costa Rodrigo Furtado Madeiro, Verfaillie Catherine
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and fatal neurodegenerative disorder, characterized by selective loss of motor neurons (MNs). A number of causative genetic mutations underlie the disease, including mutations in the fused in sarcoma (FUS) gene, which can lead to both juvenile and late-onset ALS. Although ALS results from MN death, there is evidence that dysfunctional glial cells,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.