Article

ER fusogens maintain membrane reservoir to ensure brain function

2025-04-21

Abstract excerpt

How the morphological dynamics of the endoplasmic reticulum (ER) are linked to its functions is unclear. Atlastins (ATLs), a class of GTPases, mediate ER fusion, and human mutations in ATL1 cause hereditary spastic paraplegia (HSP). Here, we show that ATL2-knockout mice are embryonic lethal with compromised development, particularly of the cerebellum. ATL2 is highly expressed in neuroglia, though ATL1 is dominant...

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Literature Corpus work: 164a9986-d470-5166-8868-61f32950b113
DOI: 10.1101/2025.04.12.648519

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