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Article

Compartment-specific transcriptome of motor neurons reveals impaired extracellular matrix signaling and activated cell cycle kinases in FUS-ALS.

Neurobiology of disease - 1 Feb 2026

Zimyanin Vitaly, Dash Banaja P, Simolka Theresa, Glaß Hannes, Pal Arun, Haidle Felix, Zarnack Kathi, Verma Riya, Khatri Vivek, Deppmann Christopher, Zunder Eli, Müller-McNicoll Michaela, Redemann Stefanie, Hermann Andreas

Abstract excerpt

Mutations in FUSED IN SARCOMA (FUS) cause juvenile-onset amyotrophic lateral sclerosis (ALS). Early pathogenesis of FUS-ALS involves impaired transcription and splicing, DNA damage response, and axonal degeneration. However, the molecular pathophysiology and the link between somatic and axonal phenotypes are still poorly understood. We evaluated whether compartment-specific transcriptome differences could...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41525886
DOI: 10.1016/j.nbd.2026.107268
PMCID: PMC13484514

Genes

FUS
PLK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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Compartment-specific transcriptome of motor neurons reveals impaired extracellular matrix signaling and activated cell cycle kinases in FUS-ALS.PMID 41525886Read ↗

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Proteomics analysis of FUS mutant human motoneurons reveals altered regulation of cytoskeleton and other ALS-linked proteins via 3'UTR binding.Semantic proximity Read ↗

Single-cell RNA sequencing across isogenic <i>FUS</i> and <i>TARDBP</i> ALS lines reveals a shared early mitochondrial dysfunction unique to motor neuronsSemantic proximity Read ↗

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