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Article

Autophagy regulates amyotrophic lateral sclerosis-linked fused in sarcoma-positive stress granules in neurons.

Neurobiology of aging - 1 Dec 2014

Ryu Hyun-Hee, Jun Mi-Hee, Min Kyung-Jin, Jang Deok-Jin, Lee Yong-Seok, Kim Hyong Kyu, Lee Jin-A

Abstract excerpt

Mutations in fused in sarcoma (FUS), a DNA/RNA binding protein, have been associated with familial amyotrophic lateral sclerosis (fALS), which is a fatal neurodegenerative disease that causes progressive muscular weakness and has overlapping clinical and pathologic characteristics with frontotemporal lobar degeneration. However, the role of autophagy in regulation of FUS-positive stress granules (SGs) and...

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Source

Identifiers

PMID: 25216585
DOI: 10.1016/j.neurobiolaging.2014.07.026

Genes

FUS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Autophagy regulates amyotrophic lateral sclerosis-linked fused in sarcoma-positive stress granules in neurons.PMID 25216585Read ↗

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Autophagy induction mitigates FUS aggregate formation and early synaptic dysfunction at the NMJ in the FUS-ALS modelSemantic proximity Read ↗

"STRESSED OUT": The role of FUS and TDP-43 in amyotrophic lateral sclerosis.Semantic proximity Read ↗

FUS ALS neurons activate major stress pathways and reduce translation as an early protective mechanism against neurodegeneration.Semantic proximity Read ↗

Yeast as a Model to Unravel Mechanisms Behind FUS Toxicity in Amyotrophic Lateral SclerosisSemantic proximity Read ↗

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