Article

Estimating genetic architecture and integrating functional annotations improve polygenic risk scores derived from GWAS summary statistics

2023-09-26

Abstract excerpt

<title>Abstract</title> <p>Constructing accurate polygenic risk scores (PRS) can benefit the prevention and early treatment of complex diseases. This can be accomplished by leveraging different information characterizing the effects of genetic variants on the diseases, and incorporating functional annotations. In this article, we propose a Genome-Wide Empirical Bayes (GWEB) method to first estimate the genetic ar...

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Literature Corpus work: bafbd962-2f6b-5f36-821f-0f512d534ef2
DOI: 10.21203/rs.3.rs-3266942/v1

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