JointPRS: A data-adaptive framework for multi-population genetic risk prediction incorporating genetic correlation.

Abstract excerpt

Genetic risk prediction for non-European populations is hindered by limited Genome-Wide Association Study (GWAS) sample sizes and small tuning datasets. We propose JointPRS, a data-adaptive framework that leverages genetic correlations across multiple populations using GWAS summary statistics. It achieves accurate predictions without individual-level tuning data and remains effective in the presence of a small...

Topics

• Humans
• Genome-Wide Association Study
• Genetic Predisposition to Disease
• Genetics, Population
• Polymorphism, Single Nucleotide
• Models, Genetic