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Article

Mutant KRAS as a critical determinant of the therapeutic response of colorectal cancer

1 Nov 2014

Abstract excerpt

Mutations in the KRAS oncogene represent one of the most prevalent genetic alterations in colorectal cancer (CRC), the third leading cause of cancer-related death in the US. In addition to their well-characterized function in driving tumor progression, KRAS mutations have been recognized as a critical determinant of the therapeutic response of CRC. Recent studies demonstrate that KRAS-mutant tumors are...

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PMID: 25815366
DOI: 10.1016/j.gendis.2014.10.002

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