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Article

KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer.

Cell - 23 Feb 2017

Burgess Michael R, Hwang Eugene, Mroue Rana, Bielski Craig M, Wandler Anica M, Huang Benjamin J, Firestone Ari J, Young Amy, Lacap Jennifer A, Crocker Lisa, Asthana Saurabh, Davis Elizabeth M, Xu Jin, Akagi Keiko, Le Beau Michelle M, Li Qing, Haley Benjamin, Stokoe David, Sampath Deepak, Taylor Barry S, Evangelista Marie, Shannon Kevin

Abstract excerpt

Investigating therapeutic "outliers" that show exceptional responses to anti-cancer treatment can uncover biomarkers of drug sensitivity. We performed preclinical trials investigating primary murine acute myeloid leukemias (AMLs) generated by retroviral insertional mutagenesis in KrasG12D "knockin" mice with the MEK inhibitor PD0325901 (PD901). One outlier AML responded and exhibited intrinsic drug resistance at...

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Source

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Identifiers

PMID: 28215705
DOI: 10.1016/j.cell.2017.01.020
PMCID: PMC5541948

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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