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Article

Targeting KRAS in colorectal cancer immunotherapy: rationale, challenges and future directions.

Biochimica et biophysica acta. Reviews on cancer - 1 Sept 2025

Zhu Gongmin, Pei Lijiao, Ye Di, Tang Qiulin, Xu Huanji, Bi Feng

Abstract excerpt

Kirsten rat sarcoma (KRAS) is frequently mutated in colorectal cancer (CRC). In recent years, mutant KRAS has shed its "undruggable" label, with two clinically approved inhibitors now available. Besides aberrantly activating intrinsic tumor cell growth signaling, oncogenic KRAS contributes to the development of an immunosuppressive tumor microenvironment (TME), especially in CRC. This suggests KRAS inhibition may...

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Identifiers

PMID: 40614879
DOI: 10.1016/j.bbcan.2025.189382

Genes

KRAS

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