Article
Molecular epidemiology and diagnostics of KRAS mutations in human cancer.
Cancer metastasis reviews - 1 Dec 2020
Timar Jozsef, Kashofer Karl
Abstract excerpt
RAS mutation is the most frequent oncogenic alteration in human cancers. KRAS is the most frequently mutated followed by NRAS. The emblematic KRAS mutant cancers are pancreatic, colorectal, lung adenocarcinomas and urogenital cancers. KRAS mutation frequencies are relatively stable worldwide in various cancer types with the one exception of lung adenocarcinoma. The frequencies of KRAS variant alleles appears...
Topics
- Animals
- Genes, ras
- Humans
- Molecular Epidemiology
- Mutation
- Neoplasms
- Proto-Oncogene Proteins p21(ras)