Genetically proxied therapeutic inhibition of antihypertensive drug targets and risk of common cancers: A mendelian randomization analysis.

doi:10.1371/journal.pmed.1003897

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Article

Genetically proxied therapeutic inhibition of antihypertensive drug targets and risk of common cancers: A mendelian randomization analysis.

PLoS medicine - 1 Feb 2022

Yarmolinsky James, Díez-Obrero Virginia, Richardson Tom G, Pigeyre Marie, Sjaarda Jennifer, Paré Guillaume, Walker Venexia M, Vincent Emma E, Tan Vanessa Y, Obón-Santacana Mireia, Albanes Demetrius, Hampe Jochen, Gsur Andrea, Hampel Heather, Pai Rish K, Jenkins Mark, Gallinger Steven, Casey Graham, Zheng Wei, Amos Christopher I, Smith George Davey, Martin Richard M, Moreno Victor

Abstract excerpt

BACKGROUND: Epidemiological studies have reported conflicting findings on the potential adverse effects of long-term antihypertensive medication use on cancer risk. Naturally occurring variation in genes encoding antihypertensive drug targets can be used as proxies for these targets to examine the effect of their long-term therapeutic inhibition on disease outcomes. METHODS AND FINDINGS: We performed a mendelian...

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PMID: 35113855
DOI: 10.1371/journal.pmed.1003897
PMCID: PMC8812899

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