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Article

Association of Antihypertensive Drug Target Genes With Psychiatric Disorders: A Mendelian Randomization Study.

JAMA psychiatry - 1 Jun 2021

Chauquet Solal, Zhu Zhihong, O'Donovan Michael C, Walters James T R, Wray Naomi R, Shah Sonia

Abstract excerpt

Importance: Observational studies have reported associations between antihypertensive medication and psychiatric disorders, although the reported direction of association appears to be dependent on drug class. Objective: To estimate the potential effect of different antihypertensive drug classes on schizophrenia, bipolar disorder, and major depressive disorder. Design, Setting, and Participants: This 2-sample...

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Identifiers

PMID: 33688928
DOI: 10.1001/jamapsychiatry.2021.0005
PMCID: PMC7948097

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