Article
Crystal structure of type I ryanodine receptor amino-terminal beta-trefoil domain reveals a disease-associated mutation "hot spot" loop.
Proceedings of the National Academy of Sciences of the United States of America - 7 Jul 2009
Amador Fernando J, Liu Shuang, Ishiyama Noboru, Plevin Michael J, Wilson Aaron, MacLennan David H, Ikura Mitsuhiko
Abstract excerpt
Muscle contraction and relaxation is regulated by transient elevations of myoplasmic Ca(2+). Ca(2+) is released from stores in the lumen of the sarco(endo)plasmic reticulum (SER) to initiate formation of the Ca(2+) transient by activation of a class of Ca(2+) release channels referred to as ryanodine receptors (RyRs) and is pumped back into the SER lumen by Ca(2+)-ATPases (SERCAs) to terminate the Ca(2+)...
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