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Article

Crystal structures of the N-terminal domains of cardiac and skeletal muscle ryanodine receptors: insights into disease mutations.

Structure (London, England : 1993) - 11 Nov 2009

Lobo Paolo Antonio, Van Petegem Filip

Abstract excerpt

Ryanodine receptors (RyRs) are channels governing the release of Ca(2+) from the sarcoplasmic or endoplasmic reticulum. They are required for the contraction of both skeletal (RyR1) and cardiac (RyR2) muscles. Mutations in both RyR1 and RyR2 have been associated with severe genetic disorders, but high-resolution data describing the disease variants in detail have been lacking. Here we present the crystal...

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Identifiers

PMID: 19913485
DOI: 10.1016/j.str.2009.08.016

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