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Article

Role of astrocyte senescence regulated by the non– canonical autophagy in the neuroinflammation associated to cerebral malaria

27 Dec 2023

Abstract excerpt

BACKGROUND: Cerebral malaria (CM) is a fatal neuroinflammatory syndrome caused (in humans) by the protozoa Plasmodium (P.) falciparum. Glial cell activation is one of the mechanisms that contributes to neuroinflammation in CM. RESULT: By studying a mouse model of CM (caused by P. berghei ANKA), we describe that the induction of autophagy promoted p21-dependent senescence in astrocytes and that CXCL-10 was part of...

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PMID: 38157948
DOI: 10.1016/j.bbi.2023.12.030

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