Article
Gene expression analysis reveals early changes in several molecular pathways in cerebral malaria-susceptible mice versus cerebral malaria-resistant mice.
BMC genomics - 6 Dec 2007
Delahaye Nicolas F, Coltel Nicolas, Puthier Denis, Barbier Mathieu, Benech Philippe, Joly Florence, Iraqi Fuad A, Grau Georges E, Nguyen Catherine, Rihet Pascal
Abstract excerpt
BACKGROUND: Microarray analyses allow the identification and assessment of molecular signatures in whole tissues undergoing pathological processes. To better understand cerebral malaria pathogenesis, we investigated intra-cerebral gene-expression profiles in well-defined genetically cerebral malaria-resistant (CM-R) and CM-susceptible (CM-S) mice, upon infection by Plasmodium berghei ANKA (PbA). We investigated...
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