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Article

FTY720 Modulates Microglia Toward Anti-inflammatory Phenotype by Suppressing Autophagy via STAT1 Pathway.

Cellular and molecular neurobiology - 1 Mar 2021

Hu Zi-Wei, Zhou Luo-Qi, Yang Sheng, Chen Man, Yu Hai-Han, Tao Ran, Wu Long-Jun, Wang Wei, Zhang Qiang, Qin Chuan, Tian Dai-Shi

Abstract excerpt

Since microglia-associated neuroinflammation plays a pivotal role in the progression of white matter diseases, modulating microglial activation has been suggested as a potential therapeutic strategy. Here, we investigated the anti-inflammatory effects of fingolimod (FTY720) on microglia and analyzed the crosstalk between microglia autophagy and neuroinflammation. Lipopolysaccharide (LPS)-induced primary cultured...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 32342246
DOI: 10.1007/s10571-020-00856-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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