Article
Genome-wide association studies and polygenic risk score phenome-wide association studies across complex phenotypes in the human phenotype project.
Med (New York, N.Y.) - 12 Jan 2024
Levine Zachary, Kalka Iris, Kolobkov Dmitry, Rossman Hagai, Godneva Anastasia, Shilo Smadar, Keshet Ayya, Weissglas-Volkov Daphna, Shor Tal, Diament Alon, Talmor-Barkan Yeela, Aviv Yaron, Sharon Tom, Weinberger Adina, Segal Eran
Abstract excerpt
BACKGROUND: Genome-wide association studies (GWASs) associate phenotypes and genetic variants across a study cohort. GWASs require large-scale cohorts with both phenotype and genetic sequencing data, limiting studied phenotypes. The Human Phenotype Project is a longitudinal study that has measured a wide range of clinical and biomolecular features from a self-assignment cohort over 5 years. The phenotypes...
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