Article
The use of phenome-wide association studies (PheWAS) for exploration of novel genotype-phenotype relationships and pleiotropy discovery.
Genetic epidemiology - 1 Jul 2011
Pendergrass S A, Brown-Gentry K, Dudek S M, Torstenson E S, Ambite J L, Avery C L, Buyske S, Cai C, Fesinmeyer M D, Haiman C, Heiss G, Hindorff L A, Hsu C-N, Jackson R D, Kooperberg C, Le Marchand L, Lin Y, Matise T C, Moreland L, Monroe K, Reiner A P, Wallace R, Wilkens L R, Crawford D C, Ritchie M D
Abstract excerpt
The field of phenomics has been investigating network structure among large arrays of phenotypes, and genome-wide association studies (GWAS) have been used to investigate the relationship between genetic variation and single diseases/outcomes. A novel approach has emerged combining both the exploration of phenotypic structure and genotypic variation, known as the phenome-wide association study (PheWAS). The...
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