Article
Human genetic variation and its contribution to complex traits.
Nature reviews. Genetics - 1 Apr 2009
Frazer Kelly A, Murray Sarah S, Schork Nicholas J, Topol Eric J
Abstract excerpt
The last few years have seen extensive efforts to catalogue human genetic variation and correlate it with phenotypic differences. Most common SNPs have now been assessed in genome-wide studies for statistical associations with many complex traits, including many important common diseases. Although these studies have provided new biological insights, only a limited amount of the heritable component of any complex...
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