Phenome-wide association study (PheWAS) for detection of pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network.

doi:10.1371/journal.pgen.1003087

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Article

Phenome-wide association study (PheWAS) for detection of pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network.

PLoS genetics - 1 Jan 2013

Pendergrass Sarah A, Brown-Gentry Kristin, Dudek Scott, Frase Alex, Torstenson Eric S, Goodloe Robert, Ambite Jose Luis, Avery Christy L, Buyske Steve, Bůžková Petra, Deelman Ewa, Fesinmeyer Megan D, Haiman Christopher A, Heiss Gerardo, Hindorff Lucia A, Hsu Chu-Nan, Jackson Rebecca D, Kooperberg Charles, Le Marchand Loic, Lin Yi, Matise Tara C, Monroe Kristine R, Moreland Larry, Park Sungshim L, Reiner Alex, Wallace Robert, Wilkens Lynn R, Crawford Dana C, Ritchie Marylyn D

Abstract excerpt

Using a phenome-wide association study (PheWAS) approach, we comprehensively tested genetic variants for association with phenotypes available for 70,061 study participants in the Population Architecture using Genomics and Epidemiology (PAGE) network. Our aim was to better characterize the genetic architecture of complex traits and identify novel pleiotropic relationships. This PheWAS drew on five...

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PMID: 23382687
DOI: 10.1371/journal.pgen.1003087
PMCID: PMC3561060

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