Article
NELL-1 in Genome-Wide Association Studies across Human Diseases.
The American journal of pathology - 1 Mar 2022
Cheng Xu, Shi Jiayu, Jia Zhonglin, Ha Pin, Soo Chia, Ting Kang, James Aaron W, Shi Bing, Zhang Xinli
Abstract excerpt
Neural epidermal growth factor-like (EGFL)-like protein (NELL)-1 is a potent and key osteogenic factor in the development and regeneration of skeletal tissues. Intriguingly, accumulative data from genome-wide association studies (GWASs) have started unveiling potential broader roles of NELL-1 beyond its functions in bone and cartilage. With exploration of the genetic variants of the entire genome in large-scale...
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