GATA4 and estrogen receptor alpha bind at SNPs rs9921222 and rs10794639 to regulate AXIN1 expression in osteoblasts.

doi:10.1007/s00439-022-02463-8

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

GATA4 and estrogen receptor alpha bind at SNPs rs9921222 and rs10794639 to regulate AXIN1 expression in osteoblasts.

Human genetics - 1 Dec 2022

Suthon Sarocha, Perkins Rachel S, Lin Jianjian, Crockarell John R, Miranda-Carboni Gustavo A, Krum Susan A

Abstract excerpt

Osteoporosis is a serious public health problem that affects 200 million people worldwide. Genome-wide association studies have revealed the association between several single nucleotide polymorphisms (SNPs) near WNT/β-catenin signaling genes and bone mineral density (BMD). The activation of β-catenin by WNT ligands is required for osteoblast differentiation. SNP rs9921222 is an intronic variant of AXIN1 (a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Axin Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to beta Catenin

Share to Estrogen Receptor alpha

Share to GATA4 Transcription Factor

Share to Genome-Wide Association Study

Share to Osteoblasts

Share to Polymorphism, Single Nucleotide

Share to Wnt Signaling Pathway

Source

Open in PubMed

Identifiers

PMID: 35678873
DOI: 10.1007/s00439-022-02463-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GATA4 and estrogen receptor alpha bind at SNPs rs9921222 and rs10794639 to regulate AXIN1 expression in osteoblasts.PMID 35678873Read ↗

Estrogen receptor alpha and NFATc1 bind to a bone mineral density-associated SNP to repress WNT5B in osteoblasts.Semantic proximity Read ↗

The osteoporosis susceptibility SNP rs188303909 at 2q14.2 regulates EN1 expression by modulating DNA methylation and E2F6 binding.Semantic proximity Read ↗

Metaanalysis Reveals Genetic Correlates of Osteoporosis PathogenesisSemantic proximity Read ↗

The osteoporosis risk variant rs9820407 at 3p22.1 acts as an allele-specific enhancer to regulate CTNNB1 expression by long-range chromatin loop formation.Semantic proximity Read ↗

Computational Characterization of Osteoporosis Associated SNPs and Genes Identified by Genome-Wide Association Studies.Semantic proximity Read ↗

Genetics of osteoporosis: accelerating pace in gene identification and validation.Semantic proximity Read ↗

Systems genetics and bioinformatics analyses using ESR1-correlated genes identify potential candidates underlying female bone developmentSemantic proximity Read ↗

Aromatase inhibitor-associated bone fractures: a case-cohort GWAS and functional genomics.Semantic proximity Read ↗

The Polymorphism at PLCB4 Promoter (rs6086746) Changes the Binding Affinity of RUNX2 and Affects Osteoporosis Susceptibility: An Analysis of Bioinformatics-Based Case-Control Study and Functional Validation.Semantic proximity Read ↗

Exploring DNA methylation profiles in the pathogenesis of human osteoporosis via whole-genome bisulfite sequencingSemantic proximity Read ↗

The genetic polymorphisms of key genes in WNT pathway (LRP5 and AXIN1) was associated with osteoporosis susceptibility in Chinese Han population.Semantic proximity Read ↗

An Osteoporosis Risk SNP at 1p36.12 Acts as an Allele-Specific Enhancer to Modulate LINC00339 Expression via Long-Range Loop Formation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.