Assessing network degeneration and phenotypic heterogeneity in genetic frontotemporal lobar degeneration by decoding FDG-PET.

doi:10.1016/j.nicl.2023.103559

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Article

Assessing network degeneration and phenotypic heterogeneity in genetic frontotemporal lobar degeneration by decoding FDG-PET.

NeuroImage. Clinical - 1 Jan 2024

Corriveau-Lecavalier Nick, Barnard Leland R, Przybelski Scott A, Gogineni Venkatsampath, Botha Hugo, Graff-Radford Jonathan, Ramanan Vijay K, Forsberg Leah K, Fields Julie A, Machulda Mary M, Rademakers Rosa, Gavrilova Ralitza H, Lapid Maria I, Boeve Bradley F, Knopman David S, Lowe Val J, Petersen Ronald C, Jack Clifford R, Kantarci Kejal, Jones David T

Abstract excerpt

Genetic mutations causative of frontotemporal lobar degeneration (FTLD) are highly predictive of a specific proteinopathy, but there exists substantial inter-individual variability in their patterns of network degeneration and clinical manifestations. We collected clinical and 18Fluorodeoxyglucose-positron emission tomography (FDG-PET) data from 39 patients with genetic FTLD, including 11 carrying the C9orf72...

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Identifiers

PMID: 38147792
DOI: 10.1016/j.nicl.2023.103559
PMCID: PMC10944211

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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