Article
The role of protective HCP5 and HLA-C associated polymorphisms in the control of HIV-1 replication in a subset of elite suppressors.
AIDS (London, England) - 19 Feb 2008
Han Yefei, Lai Jun, Barditch-Crovo Patricia, Gallant Joel E, Williams Thomas M, Siliciano Robert F, Blankson Joel N
Abstract excerpt
Elite suppressors (ES) are untreated HIV-1-infected patients who maintain undetectable viral loads. A recent whole-genome analysis identified two independent polymorphisms associated with low viral loads in untreated HIV-1 infection. We screened 16 ES; none were positive for the protective HLA complex 5 gene polymorphism, and only four were positive for the protective polymorphism associated with the HLA-C gene....
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