Age, BMI, and Type 2 Diabetes Modify the Relationship Between PNPLA3 and Advanced Fibrosis in Children and Adults With NAFLD.

doi:10.1016/j.cgh.2023.12.009

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Article

Age, BMI, and Type 2 Diabetes Modify the Relationship Between PNPLA3 and Advanced Fibrosis in Children and Adults With NAFLD.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 May 2024

Jarasvaraparn Chaowapong, Vilar-Gomez Eduardo, Yates Katherine P, Wilson Laura A, Neuschwander-Tetri Brent, Loomba Rohit, Cummings Oscar, Vos Miriam, Xanthakos Stavra, Schwimmer Jeffrey, Molleston Jean P, Sanyal Arun, Tonascia James, Chalasani Naga

Abstract excerpt

BACKGROUND & AIMS: PNPLA3 G-allele is an important determinant of disease severity in nonalcoholic fatty liver disease (NAFLD). Here, we investigated the effect of age, body mass index (BMI), and type 2 diabetes mellitus (T2DM) on the relationship between PNPLA3 G-allele and advanced fibrosis in adults and children with histologically characterized NAFLD. METHODS: A total of 1047 children and 2057 adults were...

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Identifiers

PMID: 38145725
DOI: 10.1016/j.cgh.2023.12.009
PMCID: PMC11045318

Genes

PNPLA3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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