Article
Impact of PNPLA3 rs738409 Polymorphism on the Development of Liver-Related Events in Patients With Nonalcoholic Fatty Liver Disease.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 Dec 2023
Rosso Chiara, Caviglia Gian Paolo, Birolo Giovanni, Armandi Angelo, Pennisi Grazia, Pelusi Serena, Younes Ramy, Liguori Antonio, Perez-Diaz-Del-Campo Nuria, Nicolosi Aurora, Govaere Olivier, Castelnuovo Gabriele, Olivero Antonella, Abate Maria Lorena, Ribaldone Davide Giuseppe, Fariselli Piero, Valenti Luca, Miele Luca, Petta Salvatore, Romero-Gomez Manuel, Anstee Quentin M, Bugianesi Elisabetta
Abstract excerpt
BACKGROUND AND AIMS: Nonalcoholic fatty liver disease (NAFLD) is a complex disease, resulting from the interplay between environmental determinants and genetic variations. Single nucleotide polymorphism rs738409 C>G in the PNPLA3 gene is associated with hepatic fibrosis and with higher risk of developing hepatocellular carcinoma. Here, we analyzed a longitudinal cohort of biopsy-proven NAFLD subjects with the aim...
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