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Article

Additive effects of PNPLA3 and TM6SF2 on the histological severity of non-alcoholic fatty liver disease.

Journal of gastroenterology and hepatology - 1 Jun 2018

Koo Bo Kyung, Joo Sae Kyung, Kim Donghee, Bae Jeong Mo, Park Jeong Hwan, Kim Jung Ho, Kim Won

Abstract excerpt

BACKGROUND AND AIM: We investigated the effects of PNPLA3 rs738409, TM6SF2 rs58542926, and MBOAT7-TMC4 rs641738 variants on metabolic phenotypes and their combined effects on the histological severity of non-alcoholic fatty liver disease (NAFLD). METHODS: We genotyped rs738409, rs58542926, and in biopsy-proven NAFLD patients (n = 416) and healthy controls (n = 109). Homeostasis model assessment of...

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Source

Identifiers

PMID: 29193269
DOI: 10.1111/jgh.14056

Genes

PNPLA3
MBOAT7
TMC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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