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Article

Whole tumor analysis reveals early origin of the TERT promoter mutation and intercellular heterogeneity in TERT expression.

Neuro-oncology - 5 Apr 2024

Appin Christina L, Hong Chibo, Suwala Abigail K, Hilz Stephanie, Mathur Radhika, Solomon David A, Smirnov Ivan V, Stevers Nicholas O, Shai Anny, Wang Albert, Berger Mitchel S, Chang Susan M, Phillips Joanna J, Costello Joseph F

Abstract excerpt

BACKGROUND: The TERT promoter mutation (TPM) is acquired in most IDH-wildtype glioblastomas (GBM) and IDH-mutant oligodendrogliomas (OD) enabling tumor cell immortality. Previous studies on TPM clonality show conflicting results. This study was performed to determine whether TPM is clonal on a tumor-wide scale. METHODS: We investigated TPM clonality in relation to presumed early events in 19 IDH-wildtype GBM and...

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Identifiers

PMID: 38141254
DOI: 10.1093/neuonc/noad231
PMCID: PMC10995505

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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