Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Establishment and Validation of the Detection of TERT Promoter Mutations by Human Gliomas U251 Cell Lines.

BioMed research international - 1 Jan 2021

Bai Huili, Bai Shunjie, Li Xiaosong, Zhang Yangli, Li Ying, He Fang, Cheng Wei

Abstract excerpt

Gliomas are the most common type of primary brain tumor, yet the prognosis for glioma patients remains poor. Mutations in the promoter region of the telomerase reverse transcriptase gene (TERTp) are associated with diagnosis and poor prognosis in gliomas. Here, we developed a precise and rapid Sanger sequencing assay to screen or TERTp mutations. We established the Sanger sequencing approach for the detection of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytoma
Share to Brain Neoplasms
Share to Glioma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ki-67 Antigen

Share to Oligodendroglioma

Share to Reproducibility of Results

Share to Sensitivity and Specificity

Share to Telomerase

Source

Open in PubMed Open full text

Identifiers

PMID: 34159191
DOI: 10.1155/2021/3271395
PMCID: PMC8187059

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Establishment and Validation of the Detection of TERT Promoter Mutations by Human Gliomas U251 Cell Lines.PMID 34159191Read ↗

Detection of TERT Promoter Mutations as a Prognostic Biomarker in Gliomas: Methodology, Prospects, and AdvancesSemantic proximity Read ↗

Upregulating mutations in the TERT promoter commonly occur in adult malignant gliomas and are strongly associated with total 1p19q loss.Semantic proximity Read ↗

When the Ends Are Really the Beginnings: Targeting Telomerase for Treatment of GBM.Semantic proximity Read ↗

The Sensitive Detection of Telomerase Reverse Transcriptase Promoter Mutation by Amplification Refractory Mutation System-PCR.Semantic proximity Read ↗

Classification based on mutations of TERT promoter and IDH characterizes subtypes in grade II/III gliomas.Semantic proximity Read ↗

Association of Telomerase Reverse Transcriptase Promoter Mutations with the Prognosis of Glioma Patients: a Meta-Analysis.Semantic proximity Read ↗

TERTmonitor-qPCR Detection of TERTp Mutations in Glioma.Semantic proximity Read ↗

TERT mutation in glioma: Frequency, prognosis and risk.Semantic proximity Read ↗

Paradoxical prognostic impact of TERT promoter mutations in gliomas depends on different histological and genetic backgrounds.Semantic proximity Read ↗

The Place and Prognostic Value of TERT Promoter Mutation in Molecular Classification in Grade II-III Glial Tumors and Primary Glioblastomas.Semantic proximity Read ↗

Recurrent TERT promoter mutations identified in a large-scale study of multiple tumour types are associated with increased TERT expression and telomerase activation.Semantic proximity Read ↗

Prognostic Impact of TERT Promoter Mutations in Adult-Type Diffuse Gliomas Based on WHO2021 CriteriaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.