Article
CSF1R inhibitors induce a sex-specific resilient microglial phenotype and functional rescue in a tauopathy mouse model.
Nature communications - 9 Jan 2023
Johnson Noah R, Yuan Peng, Castillo Erika, Lopez T Peter, Yue Weizhou, Bond Annalise, Rivera Brianna M, Sullivan Miranda C, Hirouchi Masakazu, Giles Kurt, Aoyagi Atsushi, Condello Carlo
Abstract excerpt
Microglia are central to pathogenesis in many neurological conditions. Drugs targeting colony-stimulating factor-1 receptor (CSF1R) to block microglial proliferation in preclinical disease models have shown mixed outcomes, thus the therapeutic potential of this approach remains unclear. Here, we show that CSF1R inhibitors given by multiple dosing paradigms in the Tg2541 tauopathy mouse model cause a...
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