Article
RNA-mediated symmetry breaking enables singular olfactory receptor choice.
Nature - 1 Jan 2024
Pourmorady Ariel D, Bashkirova Elizaveta V, Chiariello Andrea M, Belagzhal Houda, Kodra Albana, Duffié Rachel, Kahiapo Jerome, Monahan Kevin, Pulupa Joan, Schieren Ira, Osterhoudt Alexa, Dekker Job, Nicodemi Mario, Lomvardas Stavros
Abstract excerpt
Olfactory receptor (OR) choice provides an extreme example of allelic competition for transcriptional dominance, where every olfactory neuron stably transcribes one of approximately 2,000 or more OR alleles1,2. OR gene choice is mediated by a multichromosomal enhancer hub that activates transcription at a single OR3,4, followed by OR-translation-dependent feedback that stabilizes this choice5,6. Here, using...
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