Article
A feedback mechanism regulates monoallelic odorant receptor expression.
Proceedings of the National Academy of Sciences of the United States of America - 27 Jan 2004
Lewcock Joseph W, Reed Randall R
Abstract excerpt
In olfactory neurons, expression of a single odorant receptor (OR) from a repertoire of >1000 genes is required for odor coding and axonal targeting. Here, we demonstrate a role for OR protein as an essential regulator in the establishment of monoallelic OR expression. An OR-promoter-driven reporter expresses in a receptor-like pattern but, unlike a native OR, is coexpressed with an additional OR allele....
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