Article
Opposing, spatially-determined epigenetic forces impose restrictions on stochastic olfactory receptor choice.
eLife - 18 Dec 2023
Bashkirova Elizaveta V, Klimpert Nell, Monahan Kevin, Campbell Christine E, Osinski Jason, Tan Longzhi, Schieren Ira, Pourmorady Ariel, Stecky Beka, Barnea Gilad, Xie Xiaoliang Sunney, Abdus-Saboor Ishmail, Shykind Benjamin M, Marlin Bianca J, Gronostajski Richard M, Fleischmann Alexander, Lomvardas Stavros
Abstract excerpt
Olfactory receptor (OR) choice represents an example of genetically hardwired stochasticity, where every olfactory neuron expresses one out of ~2000 OR alleles in the mouse genome in a probabilistic, yet stereotypic fashion. Here, we propose that topographic restrictions in OR expression are established in neuronal progenitors by two opposing forces: polygenic transcription and genomic silencing, both of which...
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