Article
Prominent roles for odorant receptor coding sequences in allelic exclusion.
Cell - 30 Nov 2007
Nguyen Minh Q, Zhou Zhishang, Marks Carolyn A, Ryba Nicholas J P, Belluscio Leonardo
Abstract excerpt
Mammalian odorant receptors (ORs) are crucial for establishing the functional organization of the olfactory system, but the mechanisms controlling their expression remain largely unexplained. Here, we utilized a transgenic approach to explore OR gene regulation. We determined that although olfactory sensory neurons (OSNs) are capable of supporting expression of multiple functional ORs, several levels of control...
Topics
- Alleles
- Animals
- Base Sequence
- Gene Expression Regulation
- Mice
- Mice, Transgenic
- Models, Biological
- Olfactory Receptor Neurons
- Open Reading Frames
- Promoter Regions, Genetic
- Receptors, Odorant