Article
Achieving diverse and monoallelic olfactory receptor selection through dual-objective optimization design.
Proceedings of the National Academy of Sciences of the United States of America - 24 May 2016
Tian Xiao-Jun, Zhang Hang, Sannerud Jens, Xing Jianhua
Abstract excerpt
Multiple-objective optimization is common in biological systems. In the mammalian olfactory system, each sensory neuron stochastically expresses only one out of up to thousands of olfactory receptor (OR) gene alleles; at the organism level, the types of expressed ORs need to be maximized. Existing models focus only on monoallele activation, and cannot explain recent observations in mutants, especially the reduced...
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