Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An Expression Refinement Process Ensures Singular Odorant Receptor Gene Choice.

Current biology : CB - 25 Apr 2016

Abdus-Saboor Ishmail, Al Nufal Mohammed J, Agha Maha V, Ruinart de Brimont Marion, Fleischmann Alexander, Shykind Benjamin M

Abstract excerpt

Odorant receptor (OR) gene choice in mammals is a paradigmatic example of monogenic and monoallelic transcriptional selection, in which each olfactory sensory neuron (OSN) chooses to express one OR allele from over 1,000 encoded in the genome [1-3]. This process, critical for generation of the circuit from nose to brain [4-6], is thought to occur in two steps: a slow initial phase that randomly activates a single...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Olfactory Bulb

Share to Olfactory Receptor Neurons

Share to Receptors, Odorant

Source

Open in PubMed Open full text

Identifiers

PMID: 27040780
DOI: 10.1016/j.cub.2016.02.039
PMCID: PMC12952689

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An Expression Refinement Process Ensures Singular Odorant Receptor Gene Choice.PMID 27040780Read ↗

Gene switching and the stability of odorant receptor gene choice.Semantic proximity Read ↗

RNA-mediated symmetry breaking enables singular olfactory receptor choice.Semantic proximity Read ↗

Regulation of odorant receptors: one allele at a time.Semantic proximity Read ↗

Prominent roles for odorant receptor coding sequences in allelic exclusion.Semantic proximity Read ↗

Transcriptional priming and chromatin regulation during stochastic cell fate specification.Semantic proximity Read ↗

Functional interrogation of an odorant receptor locus reveals multiple axes of transcriptional regulation.Semantic proximity Read ↗

Negative feedback regulation ensures the one receptor-one olfactory neuron rule in mouse.Semantic proximity Read ↗

Achieving diverse and monoallelic olfactory receptor selection through dual-objective optimization design.Semantic proximity Read ↗

Stochastic gene expression in mammals: lessons from olfaction.Semantic proximity Read ↗

Variation in olfactory neuron repertoires is genetically controlled and environmentally modulated.Semantic proximity Read ↗

A feedback mechanism regulates monoallelic odorant receptor expression.Semantic proximity Read ↗

Odorant receptor gene choice is reset by nuclear transfer from mouse olfactory sensory neurons.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.