Article
Variation in olfactory neuron repertoires is genetically controlled and environmentally modulated.
eLife - 25 Apr 2017
Ibarra-Soria Ximena, Nakahara Thiago S, Lilue Jingtao, Jiang Yue, Trimmer Casey, Souza Mateus Aa, Netto Paulo Hm, Ikegami Kentaro, Murphy Nicolle R, Kusma Mairi, Kirton Andrea, Saraiva Luis R, Keane Thomas M, Matsunami Hiroaki, Mainland Joel, Papes Fabio, Logan Darren W
Abstract excerpt
The mouse olfactory sensory neuron (OSN) repertoire is composed of 10 million cells and each expresses one olfactory receptor (OR) gene from a pool of over 1000. Thus, the nose is sub-stratified into more than a thousand OSN subtypes. Here, we employ and validate an RNA-sequencing-based method to quantify the abundance of all OSN subtypes in parallel, and investigate the genetic and environmental factors that...
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