Article
Gene switching and the stability of odorant receptor gene choice.
Cell - 11 Jun 2004
Shykind Benjamin M, Rohani S Christy, O'Donnell Sean, Nemes Adriana, Mendelsohn Monica, Sun Yonghua, Axel Richard, Barnea Gilad
Abstract excerpt
Individual olfactory sensory neurons express only a single odorant receptor from a large family of genes, and this singularity is an essential feature in models of olfactory perception. We have devised a genetic strategy to examine the stability of receptor choice. We observe that immature olfactory sensory neurons that express a given odorant receptor can switch receptor expression, albeit at low frequency....
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