Limited clinical utility of a genetic risk score for the prediction of fracture risk in elderly subjects.

doi:10.1002/jbmr.2314

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Article

Limited clinical utility of a genetic risk score for the prediction of fracture risk in elderly subjects.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jan 2015

Eriksson Joel, Evans Daniel S, Nielson Carrie M, Shen Jian, Srikanth Priya, Hochberg Marc, McWeeney Shannon, Cawthon Peggy M, Wilmot Beth, Zmuda Joseph, Tranah Greg, Mirel Daniel B, Challa Sashi, Mooney Michael, Crenshaw Andrew, Karlsson Magnus, Mellström Dan, Vandenput Liesbeth, Orwoll Eric, Ohlsson Claes

Abstract excerpt

It is important to identify the patients at highest risk of fractures. A recent large-scale meta-analysis identified 63 autosomal single-nucleotide polymorphisms (SNPs) associated with bone mineral density (BMD), of which 16 were also associated with fracture risk. Based on these findings, two genetic risk scores (GRS63 and GRS16) were developed. Our aim was to determine the clinical usefulness of these GRSs for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 25043339
DOI: 10.1002/jbmr.2314
PMCID: PMC4281709

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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