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Article

Evaluation of the Effect of Sodium-Glucose Cotransporter 2 Inhibition on Fracture Risk: Evidence From Mendelian Randomization and Genetic Association Study.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Nov 2023

Dai Huajie, Zheng Longyi, Zhu Zheng, Geng Xin, Hou Tianzhichao, Wang Qi, Zhu Yijie, Lin Hong, Wang Shuangyuan, Zheng Ruizhi, Zhao Zhiyun, Li Mian, Lu Jieli, Xu Yu, Wang Tiange, Liu Jianmin, Ning Guang, Wang Weiqing, Bi Yufang, Zheng Jie, Xu Min

Abstract excerpt

This study aims to evaluate the causal effect of sodium-glucose cotransporter 2 (SGLT2) inhibition on bone mineral density (BMD), osteoporosis, and fracture risk using genetics. Two-sample Mendelian randomization (MR) analyses were performed utilizing two sets of genetic variants as instruments (six and two single-nucleotide polymorphisms [SNPs]) associated with SLC5A2 gene expression and glycated hemoglobin A1c...

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PMID: 37436694
DOI: 10.1002/jbmr.4880

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