Article
Single nucleotide polymorphisms in the human gene for osteoprotegerin are not related to bone mineral density or fracture in elderly women.
Calcified tissue international - 1 Jan 2004
Brändström H, Gerdhem P, Stiger F, Obrant K J, Melhus H, Ljunggren O, Kindmark A, Akesson K
Abstract excerpt
Osteoprotegerin (OPG), a secreted member of the tumor necrosis factor receptor family, is a potent inhibitor of osteoclast activation and differentiation. In animal models OPG prevents bone loss, and in humans bone resorption can be reduced by injections of OPG. OPG may also play a role in cardiovascular disease since mice lacking the OPG gene display arterial calcification. In a screening effort of the OPG gene,...
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