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Article

Autophagy supports PDGFRA-dependent brain tumor development by enhancing oncogenic signaling

18 Dec 2023

Abstract excerpt

Autophagy is a conserved cellular degradation process. While autophagy-related proteins were shown to influence the signaling and trafficking of some receptor tyrosine kinases, the relevance of this during cancer development is unclear. Here, we identify a role for autophagy in regulating platelet-derived growth factor receptor alpha (PDGFRA) signaling and levels. We find that PDGFRA can be targeted for...

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PMID: 38113891
DOI: 10.1016/j.devcel.2023.11.023

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