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Article

PDGFRA in paediatric high-grade glioma - target or distraction?

Neoplasia (New York, N.Y.) - 1 Nov 2025

Le Natalie, Chen Jingwei, Ekert Paul G, Brown Lauren M, Manoharan Neevika

Abstract excerpt

Paediatric high-grade gliomas (pHGGs) are aggressive and molecularly heterogenous paediatric brain tumours with extremely poor survival outcomes. Receptor tyrosine kinases (RTKs) are recurrently altered in a significant proportion of pHGGs and can be potentially targeted with tyrosine kinase inhibitors (TKIs). PDGFRA is the most frequently altered RTK in pHGG and as such, represents an attractive therapeutic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Platelet-Derived Growth Factor alpha

Source

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Identifiers

PMID: 40987035
DOI: 10.1016/j.neo.2025.101231
PMCID: PMC12493241

Genes

PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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