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Article

Suppression of autophagy impedes glioblastoma development and induces senescence

15 Jun 2016

Abstract excerpt

The function of macroautophagy/autophagy during tumor initiation or in established tumors can be highly distinct and context-dependent. To investigate the role of autophagy in gliomagenesis, we utilized a KRAS-driven glioblastoma mouse model in which autophagy is specifically disrupted via RNAi against Atg7, Atg13 or Ulk1. Inhibition of autophagy strongly reduced glioblastoma development, demonstrating its...

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PMID: 27304681
DOI: 10.1080/15548627.2016.1190053

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