Article
SWI/SNF: a chromatin-remodelling complex with a role in carcinogenesis.
The international journal of biochemistry & cell biology - 1 Apr 2009
Halliday Gary M, Bock Vanessa L, Moloney Fergal J, Lyons J Guy
Abstract excerpt
SWI/SNF is a chromatin-remodelling complex that makes DNA that has been compacted into nucleosomes accessible to transcription factors and repair enzymes. It does this by displacing DNA from the core histone surface. SWI/SNF consists of at least nine subunits, including one of two alternative ATPase subunits, BRM or BRG-1, that provide the energy for remodelling. As it regulates access to DNA it controls many...
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